Runners were defined using a self-administered questionnaire at the 96-month visit. This nested cohort study within the Osteoarthritis Initiative (OAI) (2004–2014) included those at least 50 years old with OA in at least one knee. Therefore, we aimed to evaluate the association of self-selected running on OA symptom and structure progression in people with knee OA. However, the effect of running, a moderate to vigorous activity, in those with knee osteoarthritis (OA), a common arthritis that occurs with aging, a high-risk group for mortality and cardiovascular events, is unclear. Higher levels of moderate to vigorous physical activity improve all-cause mortality and cardiovascular events.
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